低身長専門西新宿整形外科クリニック
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7th Floor, Nishi-Shinjuku
Daikyo Building,
Nishi-Shinjuku 7-21-3,
Shinjuku-ku, Tokyo
160-0023

 

HOME > Out-Patient Clinic for Short Stature in Children
Out-Patient Clinic for Short Stature in Children
Out-Patient Clinic for Short Stature in Children

The Most Appropriate Period for Hormone Treatment for Children

 

Growth hormone treatment is most effective in the childhood (3 years old to puberty). As shown in the graph, the effect of growth hormone treatment is remarkably decreased in the puberty. If a person is older than 20, any tratment other than surgery cannot be effective at all. Surgery at the early stage provides better bone formation.
The childhood is most important period for hormone treatment!



・Treatment in Puberty

Sex hormones promote bone maturation. Briefly, bone maturation is to change extending (growing) resilient bone of children to hard and strong bone of adults. In the puberty, components of bone (such as calcium, phosphorus, and minerals) have already changed. In this period, growth hormone is not effective than expected. .It would rather be stressful than effective for your child.



・After Puberty to Adult

The Internet is filled by a variety of information, and some adverstisements imply that bone would be extended in this period. However, it is definitely impossble. Please note that only surgely can help you if you want to extend your height.


Causes of Short Stature

Causes of Short Stature in Children

Short stature can occur even normal growth hormone is secreted.

As shown in the following figure, even normal growth hormone is secreted, events occurred in the liver after the secretion often cause shortage of IGF-1, and result in short stature in fact.

The substance which affects bone growth directly is not the growth hormone, but IGF-2.


Problems After Growth Hormone is Secreted
This is the case that factors necessary for growth are inhibited by any reasons even normal growth hormone is secreted. For the persons in this case, we use IGF-2 because the effect of growth hormone is insufficient for them.


小児低身長の原因

Classification of Short Stature

The causes of short stature include the following diaseses. 71% of them occur in healthy people.

分類


What is the Treatment for Short Stature in Children?

Our Treatment for Short Stature in Children

In Japan, health insurances partically cover hormone treatment for short stature in children. However, their coverage are more limited than that of the U.S. and Europe, and only to some patients.

 

Therefore, our clinic provides treatment with all children who concern about short stature in the range of both of services covered by health insurance designated by Ministry of Health, Labour and Welfare of Japan, and the ones not covered by health insurance designated by U.S. Food and Drug Administration.


Growth Hormone Treatment

We insert and attach a cartridge containing growth hormone (somatropin) to a dedicated holder. The needle is extremely thin as 31 gauge (0.26 mm), and there is no pain at injection. Before you use it, we will give you an instruction including a brochure, a DVD, and a day planner at our clinic .

成長ホルモン治療
Effects of Growth Hormone

In most cases, the effects are found in the first 2 years from starting the treatment, and gradually decreased over time. However, better growth is found than no treatment.
Growth hormone promotes not only the bone but also muscles. It also has the effect to decompose the fat. When starting the treatment, appetite is increased and body fat is decreased.


Before starting growth hormone treatment,
please make sure to confirm the following:

Since the hormone is naturally generated in the body, basically it has no remarkable side effects. Therefore, high safety has been demonstrated for this treatment. In some cases, headache, rash, and pain at the injection site were found at the early stage of the treatment, but these symptoms are transient. However, if your child has a gene of insulin-dependent diabetes, diabetes may be developed associated with this treatment. Therefore, please make sure to tell us if any members of your family have diabetes.

 

In addition, hypothyroidism (the disease that thyroid hormones are decreased) may occur during the treatment of short stature in children associated with GH deficiency. To prevent the disease, we regularly measure the amount of thyroid hormones by blood collection.


 

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